https://www.keithlittlewood.co.uk/blog daily 0.75 2025-09-18 https://www.keithlittlewood.co.uk/blog/defending-t3-levels-is-a-priority-yet-the-majority-still-do-not-test-it monthly 0.5 2025-09-18 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/189abf12-8ca3-4a27-a7d7-e77d0e6c2c23/thyroxine+dpletion.png Blog - Defending T3 levels is a priority yet the majority still do not test it - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/53968ea3-96e2-45d2-a8b9-7aaca63a4dfe/dbdpe.png Blog - Defending T3 levels is a priority yet the majority still do not test it T3 is a proliferative hormone that also promotes differentiation. In this GH3 cell line, despite exposure to a flame retardant, the effects of T3 are largely not affected until the dose gets high. This could be a problem with chronic bioaccumulation of these and other lipophilic (fat loving) compounds. https://www.keithlittlewood.co.uk/blog/c7j693tur04z9koeg6xg3ogn3teu7f monthly 0.5 2025-01-13 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1035c88f-f231-450e-999b-01233f7694b9/cancer%2Bresp.png Blog - Methylene blue and the big C - Make it stand out Another potent mechanism of MB’s anticancer effects is its ability to down regulate heat shock proteins (HSP), and in particular HSP70 in lung tumors, which promote survival and proliferation. Again, application of MB, decreased HSP production, and in this study also decreased proliferation. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/cef82467-2f30-4402-a6d0-2b84adf87315/HSp.png Blog - Methylene blue and the big C - Make it stand out Sanchala et al 2018 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/26e227aa-537d-49f9-820b-68ae8d820415/MB.png Blog - Methylene blue and the big C - Make it stand out Figure 1.1 Proliferative effect of methylene blue (3.19 x 10-7) on 5000 U87 cells per well at time frames of 24, 48, and 72 hours compared to dimethyl sulfoxide control (DMSO), and no treatment (NT), measure by MTT assay. Control and treatment were <0.1% of well media volume (this was also tested against a distilled H20 control with similar effects to NT). https://www.keithlittlewood.co.uk/blog/2023/11/15/do-you-really-have-anaemia monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/fb085ee4-9555-4711-8633-463c0b1692d5/bloods.png Blog - Do you really have anaemia? - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/83afa847-d76c-4d1b-a6f2-91e3384e26c0/iron%2B1.png Blog - Do you really have anaemia? - Iron in isolation is a poor marker of iron status Iron in isolation is a poor marker of iron status Multiple ways to determine a problem https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/fa789bca-2380-4bb7-8b16-880f559726a6/lipo%281%29.png Blog - Do you really have anaemia? - Lipofuscin You can observe the comparison between developing and robust physiology compared to the age or ceroid pigment called lipofuscin. Lipofuscin is the accumulation of iron ( it can also be other trace elements like copper) and unsaturated fatty acids that oxidise and damage the skin. Lipofuscin is not exclusive to the skin and shows up in organs like the brain, where it is involved in degeneration of the brain and states like dementia. https://www.keithlittlewood.co.uk/blog/2023/6/21/the-dogma-of-low-carb-diets-and-type-2-diabetes-remission-3nr3p monthly 0.5 2023-10-06 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833911-F313A3DYX5ESOK49CPEQ/dbdpe.png Blog - The dogma of low carb diets and type 2 diabetes remission. DBDPE is a novel brominated flame retardant, used as replacement for the now banned BDEs that are deemed POPs or persistent organic pollutants. They are now one of the most common household endocrine disrupters that are found in the home/work both inhaled and ingested. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833915-7IIUVU9VS6PXQIBE2NCA/d.png Blog - The dogma of low carb diets and type 2 diabetes remission. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833925-L8OZJZMAE15UX3R5GXCI/forest.png Blog - The dogma of low carb diets and type 2 diabetes remission. There aren’t many papers assessing the effects of DBDPE on thyroid function but much like its predecessors with a track record of thyroid disruption. DBDPE seems to be following suit and will be forming part of my research on thyroid disruption. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833904-4HZ8EMU69H8T5DAKSLVU/With+carbs.jpg Blog - The dogma of low carb diets and type 2 diabetes remission. - Make it stand out Kids and cells are pretty similar https://www.keithlittlewood.co.uk/blog/2023/2/10/why-fruit-juice-wont-give-you-cancer-wnzx4 monthly 0.5 2023-10-06 https://www.keithlittlewood.co.uk/blog/2023/2/10/improving-brain-health-amyloid-tau-and-energy-agjwg monthly 0.5 2023-10-06 https://www.keithlittlewood.co.uk/blog/2022/10/24/aratstale-y4e6k monthly 0.5 2023-10-06 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833381-LWB8Z4TCJCAJ484G6PQO/T4%2Bgavage%2Bvs%2Bfeed.png Blog - Hormone disruption - A rats tale - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833384-6282FDQ9UM8P2MU4ZO8G/T3%2Bgavage%2Bpic.png Blog - Hormone disruption - A rats tale - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833371-P0J5ZT4BFVC2HUWI0FKL/Hormone%2Bdisruption%2BA%2Btale%2Bof%2Btwo%2Brats.png Blog - Hormone disruption - A rats tale - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2022/7/19/disorganisation-susceptibility-part-ii-gjp5g-rgctf monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833414-VDO6JUK7MH6I1QKCWC4M/progest.png Blog - Disorganisation &amp; susceptibility Part II - Make it stand out Shah 2021 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833404-BORMJIM169D84Q9A323D/viral.png Blog - Disorganisation &amp; susceptibility Part II - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/1/13/an-open-letter-to-anyone-who-believes-that-triiodothyronine-is-dangerous-2wmms monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833472-SU50AXYO5XSGU9I41P4E/danger.jpg Blog - An open letter to anyone who believes that triiodothyronine is dangerous. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833497-38YXMBW0FFVZFH2AWLUU/T4%3AFT4+combined.png Blog - An open letter to anyone who believes that triiodothyronine is dangerous. - Make it stand out T4/FT4 combined https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833512-P1GKLDKFPJEG6ED5G1G7/EDC%2BT3.png Blog - An open letter to anyone who believes that triiodothyronine is dangerous. - Make it stand out T3/FT3 combined https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833480-SBJ52UPC8QLI2TC3G93F/TSH.png Blog - An open letter to anyone who believes that triiodothyronine is dangerous. - Make it stand out TSH https://www.keithlittlewood.co.uk/blog/2023/1/13/disorganisation-and-viral-susceptibility-dtz8m monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833459-CQ5K5Y0K9326ZIT7C9D4/metheelyne.png Blog - Disorganisation and (Viral) Susceptibility - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833451-LBIQBHXXTHGKTANYIK06/viral+suseptibility.png Blog - Disorganisation and (Viral) Susceptibility - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/1/13/thyroid-hormones-and-longevity-gr75p monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833538-WTAAPU5G1K6KSSPONMS6/Copy%2Bof%2BHey%2Bdid%2Byou%2Bhear%2Babout%2Bthe%2Bcentenarian%2Bwho%2Bfasted%252C%2Bdrank%2Blots%2Bof%2Bwater%2Band%2Btook%2Bice%2Bcold%2Bbaths.jpeg Blog - Thyroid hormones and longevity - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833544-MA33FEZ64ZKSICUYROZ9/ray+peat.png Blog - Thyroid hormones and longevity - Ray Peat Nutrition For Women Thyroid hormone is necessary for respiration on the cellular level and makes possible all higher biological functions. Without the metabolic efficiency which is promoted by thyroid hormone, life wouldn’t get much beyond the single cell stage. Without adequate thyroid, we become sluggish, clumsy, cold anemic, and subject to infections, heart diseases, headaches cancer, and many other diseases. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833564-BBM8VWIWGBD3PKQJTHLU/tsh+core.png Blog - Thyroid hormones and longevity - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833555-8PC7JC9PAOKXISA8FA4M/Copy%2Bof%2BHey%2Bdid%2Byou%2Bhear%2Babout%2Bthe%2Bcentenarian%2Bwho%2Bfasted%252C%2Bdrank%2Blots%2Bof%2Bwater%2Band%2Btook%2Bice%2Bcold%2Bbaths.jpeg Blog - Thyroid hormones and longevity - Slowing metabolic rate equals less thyroid, less complexity and an inability to restore function when chronic stressors persist. Normal vales of thyroid hormone (T3) is associated with improved function in centenarians. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833582-JVTP4W8B9LRBKDP2TC2M/when+is+tsh+too+much%3F.png Blog - Thyroid hormones and longevity - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833591-ITNIOSUB6YJZAO0G5T4D/ivan+illich.jpeg Blog - Thyroid hormones and longevity Back in the 1970s Ivan Illich prophetically wrote how medicine and industry was designed to turn as many people as possible into patients (Illich, 2003). Patients who should turn over the management of their own health into a system that’s not deigned to make them healthier; just create long term customers which ideally starts at birth and ends at death. https://www.keithlittlewood.co.uk/blog/2023/1/15/hypothyroidism-hyperglycemia-and-hufa-metabolism-fk943 monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833607-KQ4QBKVC477MLJVZRZU9/h.png Blog - Hypothyroidism, hyperglycemia and HUFA metabolism - Glycation of hemoglobin or HBa1c test is used as a marker of efficient glucose use. It can be affected by hypothyroidism and made worse by chronic and incomplete oxidation of fatty acids. . https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833604-DIW90FYZWUBAAWCUW67P/h.png Blog - Hypothyroidism, hyperglycemia and HUFA metabolism - Make it stand out Is sugar really the cause of diabetes or do fats and hormones have a role? https://www.keithlittlewood.co.uk/blog/2023/1/18/the-commonality-of-statins-and-omega-3s-6wsyl monthly 0.5 2023-01-18 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833652-IOO71RM0DPZXKFIG0AB4/Copy+of+Copy+of+Inflammation.png Blog - The commonality of statins and Omega 3s - Make it stand out Statins and Omega 3s contribute to long range disorder. https://www.keithlittlewood.co.uk/blog/2023/1/24/beyond-tsh-additional-markers-for-hypothyroidism-additional-conversations-with-your-doctor-6p4tn monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833677-H0PLVFJ4DSQRLTGCXFIJ/acid.png Blog - Beyond TSH – additional markers for hypothyroidism -additional conversations with your doctor pH balance and your toilet. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833680-Z9PFUCXUF7PL1P1J7DQT/hypo.png Blog - Beyond TSH – additional markers for hypothyroidism -additional conversations with your doctor - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833674-PYAT7M4X7E4QXT4YEYZ9/h.png Blog - Beyond TSH – additional markers for hypothyroidism -additional conversations with your doctor - Make it stand out Remember to smile and be nice when talking with your Dr. https://www.keithlittlewood.co.uk/blog/2023/1/20/fasting-and-calorific-restriction-increased-longevity-or-just-a-slower-death-6xc2f monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833664-ZQ6Z62FDUXVM80DWHRI6/Screenshot+2023-01-20+at+19.13.14.jpg Blog - Fasting and calorific restriction- Increased longevity or just a slower death? - Make it stand out “There’s an inverse relationship between the peroxidation index of skeletal muscle phospholipids and maximum lifespan of mammal and bird species of different sizes.” A.J.Hulbert https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833659-2ZV3ZDZWUV6QFAF5GI57/fast.png Blog - Fasting and calorific restriction- Increased longevity or just a slower death? - Make it stand out Does fasting really increase longevity, or a tool for those who over eat? https://www.keithlittlewood.co.uk/blog/2023/2/9/the-big-estrogen-hoax-w8epj monthly 0.5 2023-02-09 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833695-JTF9B3VDYJCGP7PSL2OK/h.png Blog - The Big Estrogen Hoax - Make it stand out Raymond Peat https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833689-PR8K8FIPSS3J1IBSEZ4G/e.png Blog - The Big Estrogen Hoax - Make it stand out Spraying folk with estrogenic pesticides seemed like a good idea https://www.keithlittlewood.co.uk/blog/2023/2/10/chronic-stress-appetite-suppression-control-and-metabolic-inflexibility-gkhen monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833767-IOJVWMAX3XBZRHAVX5N4/Metabolic+inflexibilitY+%281%29.png Blog - Chronic Stress, appetite suppression, control and metabolic inflexibility - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/2/10/autoimmunity-part-2-the-autoimmune-paleo-diet-pros-and-cans-9c9gr monthly 0.5 2023-12-30 https://www.keithlittlewood.co.uk/blog/happyhormonesdownload-4t82w monthly 0.5 2024-02-01 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833615-9QJ9RMSGVAODOTVXOIBW/happyhormones2-4.jpeg Blog - Free Happy Hormones Copy - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/2/10/autoimmunity-nmej2 monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833741-6GZKB3E1I3AXVC2ZSO0Y/Leonell+Strong.png Blog - Autoimmunity - Make it stand out '“The second contribution of genetics was the production and control of biological states that differed in cancer susceptibility and cancer resistance. This contribution made possible the discovery that the female hormone estrogen, was involved in the origin of several kinds of cancer in mice.” https://www.keithlittlewood.co.uk/blog/2023/2/26/a-bioenergetic-approach-to-restoring-gut-function-part-ii-yjscn monthly 0.5 2023-12-30 https://www.keithlittlewood.co.uk/blog/2023/2/26/body-temperature-and-health-jncsz monthly 0.5 2023-12-30 https://www.keithlittlewood.co.uk/blog/2023/2/26/better-gut-health-with-less-bacteria-54jd6 monthly 0.5 2023-12-30 https://www.keithlittlewood.co.uk/blog/2023/2/9/how-to-keep-your-chain-maintained-c49j7 monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833706-BXAXUR4L8XN2VLS808X1/n.png Blog - How to keep your (energy) chain maintained. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833702-OZSQDZXRQT3VBL3O7PV7/c.png Blog - How to keep your (energy) chain maintained. - Make it stand out Aerobic physiology and its best working order https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833712-QQRWZIZ9AWVW4B1F3B1G/1.png Blog - How to keep your (energy) chain maintained. - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/2/26/pcos-inheritance-and-stress-glk5w monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833822-4QPQUIS3L4R8PT0C1AZU/nh.png Blog - PCOS, inheritance and stress - Make it stand out Definition or decidedly lacking? https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833818-J57TDSTBJPYNWFCVX11E/pcos.png Blog - PCOS, inheritance and stress - Make it stand out PCOS traits and environmental stimulus https://www.keithlittlewood.co.uk/blog/2023/1/16/sleep-stress-sugar-eat-sugar-for-better-sleep-gywyw monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833641-SZTVEPQT54PV8JKKVPO7/corti.png Blog - Sleep, stress, sugar. Eat sugar for better sleep. - Make it stand out Cortisol profile https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833632-ULCWRBH4WFHA5IBHT3EX/sleep.jpeg Blog - Sleep, stress, sugar. Eat sugar for better sleep. - Make it stand out Transmitters of the waking and sleeping state https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833623-MFKA3HHMON49BZFBIEA9/Copy+of+Cortisol+%281%29.png Blog - Sleep, stress, sugar. Eat sugar for better sleep. - Make it stand out Sleep wake cycles and why you pee https://www.keithlittlewood.co.uk/blog/2023/3/3/is-testosterone-replacement-therapy-necessary-a2fkz monthly 0.5 2023-12-30 https://www.keithlittlewood.co.uk/blog/2023/2/26/subclinical-hypothyroidism-jm9ba monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833776-M31MFWV2B103H4XP21KI/thyr.png Blog - Subclinical Hypothyroidism - Make it stand out Thyroid function https://www.keithlittlewood.co.uk/blog/2023/3/17/sunlight-health-and-cancer-tn66r monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833891-63CBH9JJIMSELHQ89E0H/Screenshot+2023-03-17+at+17.26.05.jpg Blog - Sunlight, health and cancer - Make it stand out The more you read, the more holes in theory you find. https://www.keithlittlewood.co.uk/blog/2023/2/26/seasonal-thyroid-fluctuations-biology-and-mood-y2sw8 monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833791-EVQH2HXD73AZNBGPX5XI/Screenshot+2023-03-03+at+22.49.09.jpg Blog - Seasonal thyroid fluctuations, biology and mood - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/3/3/methylene-blue-lets-play-the-blues-nnktl monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833857-9GT0TDFB9U4YJ8VDNMBO/mb.png Blog - Methylene Blue -Let’s play the Blues - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.keithlittlewood.co.uk/blog/2023/2/26/an-energetic-approach-to-restoring-gut-function-part-1-psnps monthly 0.5 2023-12-30 https://images.squarespace-cdn.com/content/v1/64b981074261786d94268ae9/1689878833832-B6VGBZRAZUP62E6CS1Z6/d.png Blog - An energetic approach to restoring gut function: Part 1. - Make it stand out 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